Quantitatively Interpreted Enhanced Inhibition of Cytochrome P450s by Heteroaromatic Rings Containing NitrogenLEACH, Andrew G; KIDLEY, Nathan J.Journal of chemical information and modeling. 2011, Vol 51, Num 5, pp 1048-1063, issn 1549-9596, 16 p.Article

Side Chain Flexibilities in the Human Ether-a-go-go Related Gene Potassium Channel (hERG) Together with Matched-Pair Binding Studies Suggest a New Binding Mode for Channel BlockersZACHARIAE, Ulrich; GIORDANETTO, Fabrizio; LEACH, Andrew G et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 14, pp 4266-4276, issn 0022-2623, 11 p.Article

The ene reactions of nitroso compounds involve polarized diradical intermediatesLEACH, Andrew G; HOUK, K. N.Journal of the American Chemical Society. 2002, Vol 124, Num 50, pp 14820-14821, issn 0002-7863, 2 p.Article

Theoretical investigation of the origins of catalysis of a retro-Diels-Alder reaction by antibody 10F11LEACH, Andrew G; HOUK, K. N; REYLNOND, Jean-Louis et al.Journal of organic chemistry. 2004, Vol 69, Num 11, pp 3683-3692, issn 0022-3263, 10 p.Article

The origins of noncovalent catalysis of intermolecular Diels-Alder reactions by cyclodextrins, self-assembling capsules, antibodies, and RNAsesKIM, Susanna P; LEACH, Andrew G; HOUK, K. N et al.Journal of organic chemistry. 2002, Vol 67, Num 12, pp 4250-4260, issn 0022-3263, 11 p.Article

The discovery of benzanilides as c-Met receptor tyrosine kinase inhibitors by a directed screening approachALLEN, Joanne V; BARDELLE, Catherine; LEACH, Andrew G et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 18, pp 5224-5229, issn 0960-894X, 6 p.Article

A System for Encoding and Searching Markush StructuresCOSGROVE, David A; GREEN, Keith M; LEACH, Andrew G et al.Journal of chemical information and modeling. 2012, Vol 52, Num 8, pp 1936-1947, issn 1549-9596, 12 p.Article

Inhibitors of the tyrosine kinase EphB4. Part 1 Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidinesBARDELLE, Catherine; CROSS, Darren; WILLIAMS, Emma J et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 9, pp 2776-2780, issn 0960-894X, 5 p.Article

Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidinesBARDELLE, Catherine; COLEMAN, Tanya; ROBINS, Peter et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 21, pp 5717-5721, issn 0960-894X, 5 p.Article

Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposureLEACH, Andrew G; JONES, Huw D; COSGROVE, David A et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 23, pp 6672-6682, issn 0022-2623, 11 p.Article

Shapes of antibody binding sites : Qualitative and quantitative analyses based on a geomorphic classification schemeLEE, Michelle; LLOYD, Peter; XIYUN ZHANG et al.Journal of organic chemistry. 2006, Vol 71, Num 14, pp 5082-5092, issn 0022-3263, 11 p.Article

Mechanism of ene reactions of singlet oxygen. A two-step no-intermediate mechanismSINGLETON, Daniel A; CHAO HANG; SZYMANSKI, Michael J et al.Journal of the American Chemical Society. 2003, Vol 125, Num 5, pp 1319-1328, issn 0002-7863, 10 p.Article